GATE 2019 BT – Question 13

General Biology · Microbiology: Microbial diseases, host-pathogen interactions, antibiotics and resistance, two-component system, bacterial communication, viruses · 1 mark · Multiple choice

Tetracycline inhibits

Interaction between tRNA and mRNA.
Translocation of mRNA through the ribosome.
Peptidyl-transferase activity.
Binding of aminoacyl-tRNA to the ribosome.

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Show answer and explanation

Correct answer: (D) Binding of aminoacyl-tRNA to the ribosome.

Explanation

Tetracycline binds the bacterial small ribosomal subunit and blocks productive entry of aminoacyl-tRNA into the A site. This prevents addition of the next amino acid. Select D; translocation and peptide-bond formation are different mechanistic steps targeted by other antibiotic classes.

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