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GATE 2024 BT – Question 42

Genetics, Cellular and Molecular Biology · Genetics: Microbial genetics (transformation, transduction, conjugation), gene mapping, horizontal gene transfer, transposable elements · 2 marks · Multiple choice

Match the genetic disorder (Column I) with its molecular basis (Column II).

Column IColumn II
P. Sickle-cell anemia1. Mutation in nucleotide excision repair
Q. Xeroderma pigmentosum2. Trisomy of chromosome 21
R. Tay-Sachs disease3. Mutation in β-globin gene
S. Down Syndrome4. Mutation in hexosaminidase A gene
  1. P-1; Q-4; R-2; S-3
  2. P-3; Q-4; R-1; S-2
  3. P-3; Q-1; R-4; S-2
  4. P-4; Q-2; R-3; S-1

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Correct answer: (C) P-3; Q-1; R-4; S-2

Explanation

Sickle-cell anaemia is a β-globin mutation (3), xeroderma pigmentosum a defect in nucleotide excision repair (1), Tay-Sachs a hexosaminidase A mutation (4) and Down syndrome is trisomy 21 (2).