The GATE Grind

GATE 2026 BT – Question 38

Genetics, Cellular and Molecular Biology · Genetics: Chromosomal variation, sex determination, genetic disorders, population genetics, epigenetics · 2 marks · Multiple choice

Match the genetic disorders in Column I to the corresponding underlying cause in Column II

Column IColumn II
P. Klinefelter Syndrome1. X-chromosome insufficiency
Q. Turner syndrome2. DNA helicase mutations
R. Bloom syndrome3. Nucleotide excision repair defects
S. Xeroderma pigmentosum4. Extra X chromosome(s) in a male
  1. P-1; Q-3; R-4; S-2
  2. P-4; Q-1; R-2; S-3
  3. P-4; Q-2; R-3; S-1
  4. P-3; Q-2; R-4; S-1

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Correct answer: (B) P-4; Q-1; R-2; S-3

Explanation

Klinefelter syndrome (XXY) is an extra X in a male (4), Turner syndrome (XO) is a missing X (1), Bloom syndrome is caused by mutations in the BLM DNA helicase (2), and xeroderma pigmentosum is a defect in nucleotide excision repair (3).