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GATE 2026 BT – Question 37

General Biology · Immunology: Cellular and humoral immunity, antibody diversity and function, monoclonal antibodies, T-cell and B-cell development, memory · 2 marks · Multiple choice

Match the immunological terms in Column I with their function/description in the Column II

Column IColumn II
P. J gene1. Suppresses immune system by blocking calcineurin
Q. Cyclosporin2. Antibody binding site on a large molecule
R. Epitope3. Small foreign molecule which elicits an immune response only when combined with a carrier molecule
S. Hapten4. Contributes to antibody diversity
  1. P-3; Q-4; R-2; S-1
  2. P-2; Q-4; R-1; S-3
  3. P-4; Q-1; R-2; S-3
  4. P-1; Q-3; R-4; S-2

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Correct answer: (C) P-4; Q-1; R-2; S-3

Explanation

The J (joining) gene segment is recombined with V and D segments, which adds to antibody diversity (4). Cyclosporin blocks calcineurin and so suppresses T-cell activation (1). An epitope is the part of an antigen that an antibody binds (2). A hapten is a small molecule that is immunogenic only when attached to a carrier (3).