The GATE Grind

GATE 2025 BT – Question 15

General Biology · Immunology: Cellular and humoral immunity, antibody diversity and function, monoclonal antibodies, T-cell and B-cell development, memory · 1 mark · Multiple choice

The diversity in T-cell receptors is generated by

  1. gene rearrangements
  2. somatic hypermutation of rearranged V region
  3. gene conversion
  4. class switching

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Show answer and explanation

Correct answer: (A) gene rearrangements

Explanation

T-cell receptor diversity comes from V(D)J gene rearrangement and junctional diversity. Somatic hypermutation and class switching occur in B cells, which affect antibodies, not T-cell receptors.