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GATE 2020 BM – Question 47

Mammalian Cell Biology, Human Anatomy and Physiology · Nervous System · 2 marks · Multiple choice

At rest, extracellular voltage relative to the inside of a mammalian cell is ______. Intracellular and extracellular regions have higher ______ and ______ concentrations, respectively.

  1. More positive; K⁺; Na⁺
  2. More negative; K⁺; Na⁺
  3. More negative; Na⁺; K⁺
  4. More positive; Na⁺; K⁺

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Correct answer: (A) More positive; K⁺; Na⁺

Explanation

The resting cell interior is negative relative to outside, so the outside is more positive. Potassium concentration is higher intracellularly and sodium higher extracellularly. The complete combination is A. These concentration gradients underlie the membrane equilibrium potentials.

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