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GATE 2020 BT – Question 58

Genetics, Cellular and Molecular Biology · Cell Biology: Eukaryotic cell structure, cell cycle and growth control, cell-cell communication, signalling and signal transduction · 2 marks · Numerical answer

A culture starts with five human fibroblast cells. Two never divide; the other three each complete three rounds of division. At that stage, what is the total number of kinetochores in all cells?

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Correct answer: 1196 to 1196

Explanation

Three dividing founders produce $3(2^3)=24$ cells. Add the two undivided founders to obtain 26. Under the intended postdivision diploid-cell convention, each cell has 46 chromosomes and 46 kinetochores. Therefore the total is $26(46)=1196$. A replicated mitotic cell would require a different chromatid count; the question is evaluated after the completed divisions.

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