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GATE 2019 BT – Question 47

General Biology · Biochemistry: Biomolecules, biological membranes, channels and pumps, molecular motors, action potential and transport · 2 marks · Multiple choice

Which amino acid destabilizes an α helix when inserted in its middle?

  1. Proline
  2. Valine
  3. Isoleucine
  4. Leucine

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Correct answer: (A) Proline

Explanation

Proline restricts backbone conformation and lacks the usual backbone amide hydrogen for the helix’s hydrogen-bond pattern. In the middle of a regular α helix it therefore often introduces a kink or break. Select A; the other residues do not impose this distinctive proline constraint.

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