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GATE 2024 BT – Question 20

Plant, Animal and Microbial Biotechnology · Animals: Hybridoma technology, stem cells, animal cloning, transgenic, knock-out and knock-in animals · 1 mark · Multiple choice

A cultured skin fibroblast cell of a goat 'P' was fused with an enucleated ovum of a goat 'Q'. The resultant activated early embryo was then transplanted into a pseudopregnant (surrogate) female goat 'R' of the same strain as 'Q'. On completion of gestation, a female goat 'S' was born. With the exception of mitochondrial DNA, 'S' is a clone of ________.

  1. Only P
  2. Only Q
  3. Only R
  4. Both P and R

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Correct answer: (A) Only P

Explanation

This is nuclear transfer cloning. The nuclear DNA comes from the donor cell of P. Q only gives the cytoplasm (mitochondria) and R only carries the pregnancy.