Determine the correctness of [a] Embryonic stem cells are suitable for developing knockout mice; and [r] Homologous recombination is more frequent in embryonic stem cells than in somatic cells.
Both [a] and [r] are false.
Both [a] and [r] are true and [r] is the correct reason for [a].
Both [a] and [r] are true but [r] is not the correct reason for [a].
Correct answer: (B) Both [a] and [r] are true and [r] is the correct reason for [a].
Explanation
Classical knockout-mouse production targets genes by homologous recombination in cultured embryonic stem cells, selects the correctly targeted cells, and introduces them into embryos to obtain germline transmission. Their favourable gene-targeting capability supports their suitability. Thus both statements are true in the classical targeting context, and the reason explains the assertion: B.
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