GATE 2019 BT – Question 44

Plant, Animal and Microbial Biotechnology · Animals: Hybridoma technology, stem cells, animal cloning, transgenic, knock-out and knock-in animals · 2 marks · Multiple choice

Antibody-producing hybridomas are formed by fusion of

A T cell and myeloma cell.
A B cell and myeloma cell.
A macrophage and myeloma cell.
A T cell and B cell.

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Show answer and explanation

Correct answer: (B) A B cell and myeloma cell.

Explanation

An antibody-producing B lymphocyte contributes the desired immunoglobulin specificity, while the myeloma partner supplies sustained proliferation. Their fusion produces a hybridoma that can be selected and cloned for monoclonal-antibody production. Thus B.

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