GATE 2021 BT – Question 39
Match P Hashimoto’s disease, Q juvenile diabetes, R multiple sclerosis and S myasthenia gravis to: 1 brain, 2 pancreas, 3 skeletal muscle, 4 thyroid.
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Correct answer: (C) P-4,Q-2,R-1,S-3
Explanation
Match each autoimmune disease with the organ that is attacked.
- **P. Hashimoto's disease:** autoantibodies and T cells attack the **thyroid** (hypothyroidism). P-4.
- **Q. Juvenile (type 1) diabetes:** T cells destroy the insulin-making beta cells of the **pancreas**. Q-2.
- **R. Multiple sclerosis:** the immune system attacks the myelin sheath of nerves in the central nervous system, i.e. the **brain** (and spinal cord). R-1.
- **S. Myasthenia gravis:** antibodies against the acetylcholine receptor at the neuromuscular junction weaken the **skeletal muscle**. S-3.
Match: **P-4, Q-2, R-1, S-3** (option C).