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GATE 2020 BT – Question 38

General Biology · Immunology: MHC, antigen processing and presentation, regulation, tolerance, hypersensitivity, autoimmunity, immunodeficiency, graft vs host disease, vaccines · 2 marks · Multiple choice

Which statements about immune response are CORRECT?

[P] T cells are activated by antigen-presenting cells.

[Q] Foreign peptides are not presented to helper T cells by Class II MHC proteins.

[R] Dendritic cells are professional antigen-presenting cells.

  1. P and R only
  2. P and Q only
  3. Q and R only
  4. P, Q and R

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Correct answer: (A) P and R only

Explanation

Antigen-presenting cells provide peptide–MHC complexes and appropriate activation signals to T cells, making P true. Class II MHC presents peptides to CD4 helper T cells, so the negative statement Q is false. Dendritic cells are professional antigen-presenting cells, making R true. Therefore A.

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