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GATE 2025 BT – Question 37

General Biology · Biochemistry: Metabolism of carbohydrates, lipids, amino acids and nucleic acids, glycolysis, citric acid cycle, fatty acid oxidation, photosynthesis, respiration and electron transport · 2 marks · Multiple choice

Correctly match the Inhibitor with its respective Function in mitochondrial respiration.

InhibitorFunction
P. FCCP1. Inhibits cytochrome c oxidase
Q. Cyanide2. Makes the membrane permeable to protons
R. Oligomycin A3. Blocks mitochondrial uptake of succinate
S. Butyl malonate4. Inhibits ATP synthase
  1. P-2; Q-1; R-4; S-3
  2. P-2; Q-3; R-1; S-4
  3. P-2; Q-4; R-3; S-1
  4. P-3; Q-1; R-2; S-4

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Correct answer: (A) P-2; Q-1; R-4; S-3

Explanation

FCCP is an uncoupler that carries protons across the membrane (2). Cyanide binds cytochrome c oxidase (1). Oligomycin blocks the $F_0$ channel of ATP synthase (4). Butyl malonate blocks the dicarboxylate carrier that brings succinate in (3).