Hand-pump water near a landfill contains 1 mg/L arsenic. Oral cancer potency is 1.75 (kg·day)/mg. A 70 kg person drinks2 L/day for 10 years;average lifetime is 70 years. Find lifetime excess cancer risk as $n\times10^{-3}$,reporting n to three decimals.
Daily dose during exposure is $CI/BW=1(2)/70=.0285714$ mg/(kg·day). Lifetime averaging multiplies by exposure/lifetime duration,$10/70$,giving $.00408163$ mg/(kg·day). Multiply by slope factor1.75 to obtain risk $.007142857=7.142857\times10^{-3}$. Thus **n=7.143**. This is the linear lifetime-risk calculation defined by the examination inputs.
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