GATE 2020 BT – Question 51

Recombinant DNA Technology and Other Tools in Biotechnology · Molecular tools: Site-directed mutagenesis, CRISPR-Cas, biosensors, interaction tools, genomics and proteomics approaches · 2 marks · Multiple choice

Which gene-therapy statements are CORRECT?

[P] Germline therapy can cure affected individuals but not their progeny.

[Q] Germline therapy can cure affected individuals and their progeny.

[R] Somatic therapy can cure affected individuals but not their progeny.

[S] Somatic therapy can cure affected individuals and their progeny.

P and R only
P and S only
Q and R only
Q and S only

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Show answer and explanation

Correct answer: (C) Q and R only

Explanation

The intended distinction is heritability. A change in germ cells can pass into offspring, supporting Q in the simplified exam description. A change confined to somatic cells does not alter the germline and is not inherited, supporting R. Thus Q and R, C. These statements concern the conceptual inheritance distinction rather than guaranteeing a cure for every individual or descendant.

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