GATE 2019 BT – Question 58

Genetics, Cellular and Molecular Biology · Molecular Biology: Replication, transcription, splicing, translation, non-coding and micro RNA, RNA interference, DNA damage and repair · 2 marks · Numerical answer

A protein has molecular mass 22 kDa. Find the size of its coding cDNA, excluding untranslated regions, in kb to 1 decimal place.

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Correct answer: 0.6 to 0.6

Explanation

Using the usual average residue mass of 110 Da, the protein has approximately 22000/110 = 200 amino acids. Three nucleotides per amino acid give approximately 600 coding bases, or 0.6 kb. Adding a terminal stop codon would give 603 bases and the same requested rounded value.

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