The GATE Grind

GATE 2025 BT – Question 22

Genetics, Cellular and Molecular Biology · Molecular Biology: Replication, transcription, splicing, translation, non-coding and micro RNA, RNA interference, DNA damage and repair · 1 mark · Multiple select

Which of the following enzymes is/are involved in the biogenesis of miRNA?

  1. Drosha
  2. Cas9
  3. XRCC4
  4. Dicer

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Correct answer: (A) Drosha; (D) Dicer

Explanation

Drosha cuts the primary miRNA in the nucleus and Dicer cuts the pre-miRNA in the cytoplasm. Cas9 is the CRISPR nuclease and XRCC4 is a DNA repair protein (non-homologous end joining).