The GATE Grind

GATE 2025 BT – Question 47

Recombinant DNA Technology and Other Tools in Biotechnology · Computational tools: Bioinformatics resources, databases, sequence analysis, alignment and phylogeny · 2 marks · Multiple choice

Correctly match the following Bioinformatic tool/Database with its respective Utility.

Bioinformatic tool/DatabaseUtility
P. BLAST1. Database for 3D protein structures
Q. Bowtie2. Tool to identify similarity of a query sequence to existing sequences available in databanks
R. AlphaFold3. Tool to align short read DNA sequences obtained from Next-generation sequencing to a reference genome
S. PDB4. AI tool to predict protein structures
  1. P-2; Q-3; R-1; S-4
  2. P-2; Q-3; R-4; S-1
  3. P-3; Q-2; R-4; S-1
  4. P-4; Q-1; R-2; S-3

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Correct answer: (B) P-2; Q-3; R-4; S-1

Explanation

BLAST finds similar sequences in databases (2), Bowtie maps short sequencing reads to a reference genome (3), AlphaFold is an AI program that predicts protein structures (4), and the PDB is the database of 3D structures (1).