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GATE 2026 BM – Question 37

Biomaterials and Tissue Engineering · Biocompatibility and Implant Characteristics · 2 marks · Multiple choice

Which complement pathway is most likely activated on implanted biomaterials in a healthy human?

  1. Classical
  2. Lectin
  3. Alternative
  4. Extrinsic

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Correct answer: (C) Alternative

Explanation

The alternative complement pathway can activate on foreign material surfaces without requiring antigen-specific antibodies. This makes it a major route in the innate response to implanted biomaterials. The classical pathway is typically antibody-associated, lectin recognizes particular carbohydrate patterns, and extrinsic is not one of the three complement pathways. Thus C.

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